The San Francisco 49ers will head to Mexico City to take on the Arizona Cardinals on Monday, November 21, at the Azteca Stadium.

The Week 11 matchup will be a home game for Arizona. This will be the NFL’s only game in Mexico.

The 49ers were set to play an international game in Mexico in 2020 against the Cardinals, but the NFL cancelled international games because of the Covid-19 pandemic. San Francisco last played at Estadio Azteca in 2005, when they lost 31-17.